2024 Finalists

SyzOnc aims to change the therapeutic landscape for patients with devastating cancers, such as soft-tissue sarcomas and pancreatic cancer, where survival rates are low and immunotherapies rarely work. These cancers are complex ecosystems made of the cancer cells plus the tumor microenvironment, including extracellular matrix, vasculature, and immune cells. Our platform integrates advanced biological models and machine learning technologies to target the whole system and improve the efficacy of immunotherapy. Already, we have identified two hit chemical series for sarcoma and aim to develop several other programs while building our platform. We're driven to address the urgent need for novel approaches to improve survival rates for intractable cancers

juli is an AI-powered chronic condition management platform that engages patients to improve their health with a radically simple app that’s supercharged with massive passive data collection. This data also offers healthcare teams actionable insights to better care for their patients. juli has been proven to be effective through rigorous randomized controlled trials, is loved by 32k patients and has 7-figure market traction in pharma.

ergo is a software company, and our product embeds a "Make an offer with ergo" button directly onto brands' product pages, creating a new way for brands to clear inventory without having to announce a sale. On the backend, we then provide brands pricing analytics and are developing a decision engine. We launched in October of 2023 and since then have seen +160% growth of our install base, with brands across all different product categories using our software.

Vertical Horizons is revolutionizing energy efficiency in energy- and carbon-intensive data centers with Vertical Gallium Nitride (GaN) technology. Developed from over 8 years of research at MIT, our patented semiconductor innovation delivers unparalleled advantages over silicon-based devices, including improved efficiency, higher reliability, smaller footprint, and reduced energy loss. By deploying Vertical GaN, data centers can achieve a 40% improvement in energy efficiency in power conversion, reduce the need for cooling, slash operating costs by 20%, and significantly reduce carbon emissions. Beyond data centers, our vertical GaN technology can be applied across high-power applications including electric vehicles, electric vehicle charging, microgrids, and medical devices, with a total addressable market of over $14 Billion.

Smarty is an AI-powered conversational calendar and EA for small business owners & solopreneurs, who need to capture everything on their plate in one place and universal inbox so they can plan their best day, every day. Smarty helps you create routines, stick to them, and automate those pesky administrative tasks with conversational commands (like, creating calendar events: "Coffee with Stella at Blue Bottle at 3pm CT", or drafting and sending emails: "Send a thank you to Ash at 3pm tomorrow").

Making our homes climate-friendly is way too hard. From research to crunching numbers to finding contractors, most homeowners give up. Jane is a climate platform that makes upgrades easy. We design smarter climate plans to help homeowners discover options, budget costs, and plan projects. If homeowners want an upgrade, they can “checkout” and automatically get project quotes from contractors we trust.

NeuroBionics is building the future of precision bioelectronic medicine by developing the next generation of implantable devices capable of delivering deep brain stimulation (DBS) without the need for open brain surgery, improving the lives of millions suffering from conditions like Parkinson's disease, essential tremor, stroke, epilepsy, and depression. Leveraging over a decade of innovation at MIT, NeuroBionics was co-founded by Drs. MJ Antonini, Nicki Driscoll, and Prof. Polina Anikeeva with the mission to expand access to brain therapy. We’ve developed microscopic, flexible, bioelectronic fibers the size of human hair that are capable of recording and stimulating neural activity, delivering drugs, and ablating tissue. We guide our fibers through the blood vessels using an endovascular approach and deliver them into deep brain regions where they deliver therapeutic stimulation.

Mithril Technologies is addressing a gap in advancement of GEO antenna technologies with a uniquely flexible mesh reflector antenna design. Deployable mesh reflector antennas have been largely passive for decades, limiting their uses. Now, Mithril has developed an electrostatic actuation technique to actively steer, shape and focus the beam in real-time. Our design has uses in space domain awareness, signal intelligence, GEO satellite communications and radar for weather monitoring from space.